3-phospho-ᴅ-glycerate dehydrogenases (PGDH, or SerA) are involved in the first step of the phosphorylated pathway of L-serine biosynthesis from 3-phosphoglycerate, an intermediate of glycolysis. They reversibly oxidize ᴅ-3-phosphoglycerate to hydroxypyruvic acid phosphate utilizing NAD+ as a cofactor, the respective aspartate residue defining the specificity towards NAD(H) is highly conserved within the subfamily. According to the published biochemical studies, SERA members rarely catalyze other reactions.
| Accession | Protein name | Subfamily | Organism | Kingdom | Kinetically characterized substrates | Highest efficiency substrate | Structures |
|---|---|---|---|---|---|---|---|
| C7JH84_ACEP3 | D-3-phosphoglycerate dehydrogenase | SERA | Acetobacter pasteurianus IFO 3283-01 | Bacteria | - | - - | |
| Q3M6M2_ANAVT | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Anabaena variabilis | Bacteria | - | - - | |
| O67741_AQUAE | serA; D-3-phosphoglycerate dehydrogenase | SERA | Aquifex aeolicus | Bacteria | - | - - | |
| SERA2_ARATH | D-3-phosphoglycerate dehydrogenase | SERA | Arabidopsis thaliana (thale cress) | Eukaryotes | 3-phosphoglycerate | 3-phosphoglycerate PMID:24368794 | |
| SERA3_ARATH | D-3-phosphoglycerate dehydrogenase | SERA | Arabidopsis thaliana (thale cress) | Eukaryotes | 3-phosphoglycerate | 3-phosphoglycerate PMID:24368794 | |
| SERA1_ARATH | EDA9; D-3-phosphoglycerate dehydrogenase | SERA | Arabidopsis thaliana (thale cress) | Eukaryotes | - | - - | |
| SERA_ARCFU | phosphoglycerate dehydrogenase (serA) | SERA | Archaeoglobus fulgidus DSM 4304 | Archaea | - | - - | |
| A2QYK6_ASPNC | An12g01580; D-3-phosphoglycerate dehydrogenase | SERA | Aspergillus niger | Eukaryotes | - | - - | |
| ang:ANI_1_348154 | An17g02330; D-3-phosphoglycerate dehydrogenase 1 | SERA | Aspergillus niger | Eukaryotes | - | - - | |
| SERA_BACSU | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Bacillus subtilis subsp. subtilis 168 | Bacteria | - | - - | |
| Q8A8L5_BACTN | D-3-phosphoglycerate dehydrogenase | SERA | Bacteroides thetaiotaomicron | Bacteria | - | - - | |
| Q8G4R3_BIFLO | serA; D-3-phosphoglycerate dehydrogenase | SERA | Bifidobacterium longum NCC2705 | Bacteria | - | - - | |
| Q7W0H7_BORPE | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Bordetella pertussis Tohama I | Bacteria | - | - - | |
| SERA_BOVIN | PHGHRC; phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Bos taurus (cow) | Eukaryotes | - | - - | |
| Q2YK82_BRUA2 | Amino acid-binding ACT:D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain:D-isomer specific 2-hydroxyacid dehydrogenase | SERA | Brucella abortus | Bacteria | - | - - | 3K5P |
| Q8YIU3_BRUME | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Brucella melitensis bv. 1 16M | Bacteria | - | - - | |
| Q8YBS3_BRUME | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Brucella melitensis bv. 1 16M | Bacteria | - | - - | |
| O17626_CAEEL | C31C9.2; Uncharacterized protein | SERA | Caenorhabditis elegans (nematode) | Eukaryotes | - | - - | |
| Q0PA07_CAMJE | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 | Bacteria | - | - - | |
| Q3AQU0_CHLCH | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Chlorobium chlorochromatii | Bacteria | - | - - | |
| SLCC_CHRSD | (S)-sulfolactate dehydrogenase | SERA | Chromohalobacter salexigens | Bacteria | 3-sulfopyruvate, sulfolactate | sulfolactate PMID:20007648 | |
| Q97N23_CLOAB | serA; D-3-phosphoglycerate dehydrogenase | SERA | Clostridium acetobutylicum ATCC 824 | Bacteria | - | - - | |
| Q8NQY7_CORGL | Cgl1284; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Corynebacterium glutamicum ATCC 13032 (Kyowa Hakko) | Bacteria | - | - - | |
| B1WNQ5_CYAA5 | serA; D-3-phosphoglycerate dehydrogenase | SERA | Cyanothece sp. ATCC 51142 | Bacteria | - | - - | |
| F1QEY8_DANRE | phGHRC, fb38f06, wu:fb38f06, zgc:65956; phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Danio rerio (zebrafish) | Eukaryotes | - | - - | |
| D3PCL0_DEFDS | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Deferribacter desulfuricans | Bacteria | - | - - | |
| Q3Z8V8_DEHM1 | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Dehalococcoides mccartyi 195 | Bacteria | - | - - | |
| Q9RUU0_DEIRA | D-3-phosphoglycerate dehydrogenase | SERA | Deinococcus radiodurans | Bacteria | - | - - | |
| Q24YY4_DESHY | hypothetical protein | SERA | Desulfitobacterium hafniense Y51 | Bacteria | - | - - | |
| Q24NC0_DESHY | hypothetical protein | SERA | Desulfitobacterium hafniense Y51 | Bacteria | - | - - | |
| SERA_DICDI | serA; 3-phosphoglycerate dehydrogenase | SERA | Dictyostelium discoideum (cellular slime mold) | Eukaryotes | - | - - | |
| Q9VKI8_DROME | CG6287 gene product from transcript CG6287-RA (EC:1.1.1.95) | SERA | Drosophila melanogaster (fruit fly) | Eukaryotes | - | - - | |
| B2KCL9_ELUMP | putative phosphoglycerate dehydrogenase | SERA | Elusimicrobium minutum | Bacteria | - | - - | |
| Q76KF5_ENTHI | D-3-phosphoglycerate dehydrogenase, putative | SERA | Entamoeba histolytica | Eukaryotes | 3-phosphoglycerate | 3-phosphoglycerate PMID:25294608 | 4NJO (NAD, formic acid) PMID:25294608 4NFY PMID:25294608 4NJM (3‑phosphoglyceric acid) PMID:25294608 |
| SERA_ECOLI | D-3-phosphoglycerate dehydrogenase | SERA | Escherichia coli K-12 MG1655 | Bacteria | 3-phosphoglycerate, 2-ketoglutarate | 3-phosphoglycerate PMID:15668250 | 1YBA (NAD, 2‑oxoglutaric acid) PMID:15823035 1PSD (NAD) PMID:7719856 1SC6 (NAD) PMID:15035616 2P9C (NAD) PMID:17459882 2P9E (NAD) PMID:17459882 2P9G (NAD) PMID:17459882 2PA3 (NAD) PMID:17459882 |
| A5FH27_FLAJ1 | D-isomer specific 2-hydroxyacid dehydrogenase | SERA | Flavobacterium johnsoniae | Bacteria | - | - - | |
| E1C7Y3_CHICK | PHGHRC; phosphoglycerate dehydrogenase | SERA | Gallus gallus (chicken) | Eukaryotes | - | - - | |
| Q5KXQ4_GEOKA | phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Geobacillus kaustophilus | Bacteria | - | - - | |
| Q74DW7_GEOSL | serA; D-3-phosphoglycerate dehydrogenase | SERA | Geobacter sulfurreducens PCA | Bacteria | - | - - | |
| SERA_HAEIN | serA; D-3-phosphoglycerate dehydrogenase | SERA | Haemophilus influenzae Rd KW20 (serotype d) | Bacteria | - | - - | |
| Q5UZ36_HALMA | serA1; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Haloarcula marismortui | Archaea | - | - - | |
| D4GY36_HALVD | serA3; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Haloferax volcanii | Archaea | - | - - | |
| O25158_HELPY | D-3-phosphoglycerate dehydrogenase | SERA | Helicobacter pylori 26695 | Bacteria | - | - - | |
| SERA_HUMAN | PHGHRC, 3-PGHRC, 3PGHRC, HEL-S-113, NLS, NLS1, PDG, PGAD, PGD, PGHRC, PHGHRCD, SERA; phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Homo sapiens (human) | Eukaryotes | - | - - | 2G76 (NAD, malate ion) 5N53 ((3‑chloranyl‑4‑methoxy‑phenyl)ethanamide (8NB)) PMID:27564259 |
| A6TDS4_KLEP7 | serA; D-3-phosphoglycerate dehydrogenase | SERA | Klebsiella pneumoniae subsp. pneumoniae MGH 78578 | Bacteria | - | - - | |
| F9UT10_LACPL | serA; D-3-phosphoglycerate dehydrogenase | SERA | Lactobacillus plantarum WCFS1 | Bacteria | - | - - | |
| Q9CHW4_LACLA | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Lactococcus lactis subsp. lactis Il1403 | Bacteria | - | - - | |
| Q03W66_LEUMM | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Leuconostoc mesenteroides subsp. mesenteroides ATCC 8293 | Bacteria | - | - - | |
| Q8Y3L1_LISMO | D-3-phosphoglycerate dehydrogenase | SERA | Listeria monocytogenes EGD-e | Bacteria | - | - - | |
| Q6LWW6_METMP | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Methanococcus maripaludis S2 | Archaea | - | - - | |
| B0JX04_MICAN | serA; D-3-phosphoglycerate dehydrogenase | SERA | Microcystis aeruginosa | Bacteria | - | - - | |
| SERA_MOUSE | PhGHRC, 3-PGHRC, 3PGHRC, 4930479N23, A10, PGAD, PGD, PGHRC, SERA; 3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Mus musculus (mouse) | Eukaryotes | - | - - | |
| SERA_MYCTU | serA1; D-3-phosphoglycerate dehydrogenase | SERA | Mycobacterium tuberculosis H37Rv | Bacteria | 3-phosphoglycerate | 3-phosphoglycerate PMID:15668250 | 1YGY PMID:15668249 3DC2 PMID:18627175 3DDN PMID:18627175 |
| Q1CYP3_MYXXD | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Myxococcus xanthus | Bacteria | - | - - | |
| A7SFV8_NEMVE | hypothetical protein | SERA | Nematostella vectensis (sea anemone) | Eukaryotes | - | - - | |
| A9A1H5_NITMS | NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase | SERA | Nitrosopumilus maritimus | Archaea | - | - - | |
| Q8YVT4_NOSS1 | phosphoglycerate dehydrogenase | SERA | Nostoc sp. PCC 7120 | Bacteria | - | - - | |
| Q7XMP6_ORYSJ | Os04g0650800 | SERA | Oryza sativa japonica (Japanese rice) (RefSeq) | Eukaryotes | - | - - | |
| Q0DAG1_ORYSJ | Os06g0655100 | SERA | Oryza sativa japonica (Japanese rice) (RefSeq) | Eukaryotes | - | - - | |
| C6CU86_PAESJ | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Paenibacillus sp. JDR-2 | Bacteria | - | - - | |
| D4GM95_PANAM | serA; SerA | SERA | Pantoea ananatis LMG 20103 | Bacteria | - | - - | |
| B7FY72_PHATC | 2-hydroxyacid dehydrogenase (EC:1.1.1.95) | SERA | Phaeodactylum tricornutum | Eukaryotes | - | - - | |
| B7FY73_PHATC | hypothetical protein | SERA | Phaeodactylum tricornutum | Eukaryotes | - | - - | |
| D5ERW2_PRER2 | serA; D-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Prevotella ruminicola | Bacteria | - | - - | |
| Q7VAM4_PROMA | serA; D-3-phosphoglycerate dehydrogenase | SERA | Prochlorococcus marinus SS120 | Bacteria | - | - - | |
| Q6A895_PROAC | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Propionibacterium acnes KPA171202 | Bacteria | - | - - | |
| Q9I6H5_PSEAE | serA; D-3-phosphoglycerate dehydrogenase | SERA | Pseudomonas aeruginosa PAO1 | Bacteria | - | - - | |
| Q8ZTC7_PYRAE | D-3-phosphoglycerate dehydrogenase | SERA | Pyrobaculum aerophilum | Archaea | - | - - | |
| O50095_PYRHO | 307aa long hypothetical phosphoglycerate dehydrogenase | SERA | Pyrococcus horikoshii | Archaea | - | - - | 1WWK (NAD) |
| Q2K4M6_RHIEC | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Rhizobium etli CFN 42 | Bacteria | - | - - | |
| SER33_YEAST | SER33; phosphoglycerate dehydrogenase SER33 (EC:1.1.1.95) | SERA | Saccharomyces cerevisiae (budding yeast) | Eukaryotes | 3-phosphoglycerate | 3-phosphoglycerate PMID:12525494 | |
| SERA_YEAST | SER3; phosphoglycerate dehydrogenase SER3 (EC:1.1.1.95) | SERA | Saccharomyces cerevisiae (budding yeast) | Eukaryotes | 3-phosphoglycerate | 3-phosphoglycerate PMID:12525494 | |
| Q8Z3W3_SALTI | serA; D-3-phosphoglycerate dehydrogenase | SERA | Salmonella enterica subsp. enterica serovar Typhi CT18 | Bacteria | - | - - | |
| Q92MA3_RHIME | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Sinorhizobium meliloti 1021 | Bacteria | - | - - | |
| Q2NRE1_SODGM | D-3-phosphoglycerate dehydrogenase | SERA | Sodalis glossinidius (Glossina spp.) | Bacteria | - | - - | |
| sau:SA1545 | serA; D-3-phosphoglycerate dehydrogenase | SERA | Staphylococcus aureus subsp. aureus N315 (MRSA/VSSA) | Bacteria | - | - - | |
| Q9Z564_STRCO | SC8D9.27, serA; D-3-phosphoglycerate dehydrogenase | SERA | Streptomyces coelicolor | Bacteria | - | - - | |
| Q97ZK1_SULSO | serA-1; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Sulfolobus solfataricus P2 | Archaea | - | - - | |
| Q972A9_SULTO | D-3-phosphoglycerate dehydrogenase | SERA | Sulfolobus tokodaii | Archaea | - | - - | 2EKL (NAD) |
| Q7U8S8_SYNPX | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Synechococcus sp. WH8102 | Bacteria | - | - - | |
| syn:sll1908 | serA; D-3-phosphoglycerate dehydrogenase | SERA | Synechocystis sp. PCC 6803 | Bacteria | - | - - | |
| Q5JGC4_THEKO | D-3-phosphoglycerate dehydrogenase | SERA | Thermococcus kodakarensis | Archaea | - | - - | |
| B5YKK8_THEYD | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Thermodesulfovibrio yellowstonii | Bacteria | - | - - | |
| HPR_THEMA | D-3-phosphoglycerate dehydrogenase | SERA | Thermotoga maritima MSB8 | Bacteria | - | - - | |
| Q9WYG2_THEMA | phosphoglycerate dehydrogenase | SERA | Thermotoga maritima MSB8 | Bacteria | - | - - | |
| Q72K32_THET2 | D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Thermus thermophilus HB27 | Bacteria | - | - - | |
| Q9KP92_VIBCH | D-3-phosphoglycerate dehydrogenase | SERA | Vibrio cholerae O1 biovar El Tor N16961 | Bacteria | - | - - | |
| Q8P9M8_XANCP | serA; D-3-phosphoglycerate dehydrogenase | SERA | Xanthomonas campestris pv. campestris ATCC 33913 | Bacteria | - | - - | |
| A1L3N1_XENLA | phGHRC; phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Xenopus laevis (African clawed frog) | Eukaryotes | - | - - | |
| A0A0B6NXZ1_YERPE | serA; D-3-phosphoglycerate dehydrogenase (EC:1.1.1.95) | SERA | Yersinia pestis CO92 (biovar Orientalis) | Bacteria | - | - - | |
| Q5NLV1_ZYMMO | D-3-phosphoglycerate dehydrogenase | SERA | Zymomonas mobilis subsp. mobilis ZM4 | Bacteria | - | - - |